"but no correlation could be made between the prolactin levels and side effects hypothetically attributable to prolactin"...
Whole-cell radioligand binding studies indicate that risperidone interacts in an irreversible manner with the h5-HT7 receptor, thus producing the inactivation...
RISPERIDONE GENOMEWIDE ASSOCIATION STUDIES (GWAS) to search for genetic variation affecting the susceptibility to metabolic side effects
"We present epigenetic mechanisms of various psychoactive drugs. Epigenetic modulations in the pharmacology and toxicology of typical and atypical antipsychotic."
"It is becoming increasingly apparent that chemicals can cause changes in gene expression that persist long after exposure has ceased"
Epigenome refers to a "hidden" genetic code,not the one that contains info for building protein molec, but the one that determines when those genes are turned on/off
"Then, differential regulation of a key gene(s) in daughter cells could start a cascade of downstream-regulated events to promote symmetric or asymmetric mode (...)"
"The results indicate that clozapine, risperidone and haloperidol cause substantial reductions in the A subunit of Calcineurin but not CN B at both the RNA and (..)"
"Stimulation of 5-HT2 Receptors in Prefrontal Pyramidal Neurons Inhibits Cav1.2 L-Type Ca2+Currents Via a PLCβ/IP3/Calcineurin Signaling Cascade"
"Serotonin regulates calcium homeostasis in lactation by epigenetic activation of Hedgehog signaling"... risperidone & 9hydroxyrisperidone block Serotonin Receptors
"Mechanistic investigations on the etiology of Risperdal(®) Consta(®)-induced bone changes in female Wistar Hannover rats."IS THIS DRUG METABOLIZED BY CYP450 TOO?
"The mammary gland has a switch to turn lactation on and off.Mammary genes are controlled in groups, and some genes exist in “neighborhoods.”
Why is the Graphic no more available?http://biograph.be/concept/show/C1655409/C0073393?id=C0073393http://biograph.be/concept/show/C1655409/C0073393?id=C0524620
In hippocampal neurons, the scaffold protein AKAP79 recruits the phosphatase calcineurin to L-type Ca2+ channels and couples Ca2+ influx to activation of calcineurin
Department of Psychiatry, University of British ColumbiaDouble-blind placebo-controlled crossover trial.
Risperidone DOES Pituitary Gland Tumors, and NO MATTER if risperinode raises the prolactin, these tumors ARE NOT prescisely Prolactinomas as a "must"...
Studies provided convincing evidence that change to the tumour epigenome aren't simply epiphenomena but have functional consequences in pituitary tumours evolution
High doses of calcitonin, administered to rats for 6 months or longer, increases the incidence of alpha-subunit-producing pituitary tumors
Source data confirms an independent association of risperidone and hypocalcemia... there was significant correlation between risperidone dose and serum calcium...
These measurements were consistent with the facts that the tumors were not of somatotrope, lactotrope or corticotrope origin as assessed by immunohistochemical (...)
If Risperidone silences the Calcitonin receptor gene on chromosome11 by an epigenetic effect, then the calcitonin get's raised like if taking it as a supplement
The actual number of people known to have developed pituitary tumors due to risperidone remains unclear, because many adverse drug reactions are not reported to FDA
The Role of Epigenetic Modification in Tumorigenesis and Progression of Pituitary Adenomas: A Systematic Review of the Literature
RISPERIDONE'S role in the growth of prolactinoma is not yet conclusive... look it with your own eyes... just click it!!
Salmon calcitonin induces pituitary tumor in rats - In addition, serum concentrations of prolactin and TSH were lower (TUMORED RATS) than in the controls...
Whole-cell radioligand binding studies indicate that risperidone interacts in an irreversible manner with the h5-HT7 receptor, thus producing the inactivation
What does it happen if the CYP2R1 get's silenced? Your body will develop resistence to the Vitamin D3. The CYP2R1 gene controls the Vitamin D3: it's in chromosome 11
"Neuromodulatory effect of Gαs- or Gαq-coupled G-protein-coupled receptor on NMDA receptor selectively activates the NMDA receptor/Ca2+/calcineurin/cAMP respons(..)"
"Our laboratory is studying the epigenetic basis of normal development and disease, including cancer, aging, and neuropsychiatric illness"
Epigenetic Drug & Diagnostic Pipelines, DNA methylation, HDAC inhibitors, and emerging new targets, Insight Pharma Reports
El Gen que controla los receptores de (Dopamina D2) ESTA EN EL CROMOSOMA 11, risperidona lo bloquea y la farmaceutica dice que su mecanismo de accion es desconocido
These macromolecules belong to a large family of related sequences known as the G protein-coupled receptors... COME ON!!!!???
Nuclear Transloc. of Calcium/Calmodulin-dependent Protein Kinase IIδ3 Prom. by Protein Phosphatase-1 Enhances Brain-derived Neurotrophic F Exp in Dopaminergic Neuron
High and low levels of ionized serum calcium concentration can produce characteristic changes on the electrocardiogram.
Electroencephalographic Criteria of Hypocalcemia and Hypercalcemia: Spikes occurred only in hypocalcemia whereas triphasic waves were seen only in hypercalcemia
The industry keeps all the resulting data secret, protected by current patent law from the critical intellects of independent reviewers...
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